The central idea of using PLSR in interpretation of microarray time
series data was first presented by Johansson, Lindgren, Berglund,
Bioinformatics,19,2003) and the approach contains the following
steps:
- Expression profiles are related to a
matrix containing
cell cycle information
- Two PLSR models, one for each column in
,
and
and
represent sine and cosine
curves at different phases. Modelled as
and
- Plot genes onto the
plane
from the two models. This shows a circular like plot of points
(i.e. genes) representing the cell cycle. Genes far from the origin
are the most important ones
Bjørn Kåre Alsberg
2006-04-06