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According to
[4], one should not use print-tip normalisation on Agilent
arrays, where one should use global loess instead. This method is also unreliable for small
arrays with less than spots per print-tip group. Larger arrays
may behave like this if the number of spots with non-missing M-values
is small for one or more of the print-tip groups. If this is the case,
one should use global loess, or the empirical Bayes compromise between
print-tip and global loess normalisation, ``robustspline''.